George Kittle will lead the San Francisco 49ers into their game versus the Buffalo Bills at Highmark Stadium on Sunday at 8:20 p.m. ET.
The 49ers have excelled on both sides of the ball this season, ranking fourth-best in total offense (384.5 total yards per game) and fifth-best in total defense (304.3 total yards allowed per game). The Bills are compiling 345.3 yards per game on offense, which ranks them 13th in the NFL. Defensively, they rank 15th, giving up 329.1 yards per contest.
49ers vs Bills: live streaming info, TV channel & game time
- Game day: Sunday, December 1, 2024
- Game time: 8:20 p.m. ET
- Location: Orchard Park, New York
- Stadium: Highmark Stadium
- TV Channel: NBC
- Live stream: Watch Redzone & other NFL content all season long on Fubo
- Live stream: Watch on Peacock!
49ers vs Bills betting lines
NFL odds courtesy of BetMGM. Odds updated Sunday at 2:45 p.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
- Spread Favorite: Bills (-6.5)
- Moneyline: Bills (-285), 49ers (+231)
- Total: 44.5 points
Watch Bills vs. 49ers on Fubo!