The San Francisco 49ers (5-6) head to the Buffalo Bills (9-2) for a pivotal Week 13 matchup.
San Francisco enters looking to slam the brakes on a two-game skid, while Buffalo wants to stay within a game of Kansas City and the AFC’s No. 1 seed.
Despite consecutive losses, San Francisco enters Week 13 just a game outside first place in the NFC West and a win over the Bills could dramatically shift the 49ers’ fortunes.
The 49ers are expecting the return of starting quarterback Brock Purdy, though San Francisco still has a lengthy list of starters that will be on the sidelines.
As kickoff approaches, here’s how to watch the 49ers game, including time, TV schedule and streaming information:
What channel is 49ers vs Bills game on today? Time, TV schedule
TV Channel: NBC
Start time: 5:20 p.m. PT
49ers vs. Bills will broadcast nationally on NBC in Week 13 of the 2024 NFL season. Play-by-play broadcaster Mike Tirico and color analyst Cris Collinsworth will call the game from the booth at Highmark Stadium, with Melissa Stark reporting from the sidelines.
Where to watch 49ers vs Bills on livestream
Streaming options for the game include Peacock.
Watch 49ers vs Bills live on Peacock
49ers vs Bills predictions, picks, odds
Buffalo 30, San Francisco 20: The return of starting quarterback Brock Purdy provides an early lift, but missing left tackle Trent Williams and left guard Aaron Banks figures to create problems at some point.
Defensively, San Francisco has even more to worry about. Defensive end Nick Bosa, defensive tackle Jordan Elliott, linebacker Dre Greenlaw and cornerback Deommodore Lenoir have all been ruled out.
Ultimately, the multitude of injuries are too much to overcome against one of the NFL’s best in their house.
ODDS: Buffalo -6
O/U: 44.5
All NFL Odds via BetMGM.
49ers schedule 2024
- Sept. 9: vs. New York Jets (W, 32-19)
- Sept. 15: at Minnesota (L, 23-17)
- Sept. 22: at Los Angeles Rams (L, 27-24)
- Sept. 29: at New England (W, 30-13)
- Oct. 6: vs. Arizona (L, 24-23)
- Oct. 10: at Seattle (W, 36-24)
- Oct. 20: vs. Kansas City (L, 28-18)
- Oct. 27: vs. Dallas (W, 30-24)
- Nov. 3: BYE WEEK
- Nov. 10: at Tampa Bay (W, 23-20)
- Nov. 17: vs. Seattle (L, 20-17)
- Nov. 24: at Green Bay (L, 38-10)
- Dec. 1: at Buffalo
- Dec. 8: vs. Chicago
- Dec. 12: vs. Los Angeles Rams
- Dec. 22: at Miami
- Dec. 30: vs. Detroit
- Jan. 5: at Arizona
- Record: 5-6
Bills schedule 2024
- Sept. 8: vs. Arizona (W, 34-28)
- Sept. 12: at Miami (W, 31-10)
- Sept. 23: vs. Jacksonville (W, 47-10)
- Sept. 29: at Baltimore (L, 35-10)
- Oct. 6: at Houston (L, 23-20)
- Oct. 14: at New York Jets (W, 23-20)
- Oct. 20: vs. Tennessee (W, 34-10)
- Oct. 27: at Seattle (W, 31-10)
- Nov. 3: vs. Miami (W, 30-27)
- Nov. 10: at Indianapolis (W, 30-20)
- Nov. 17: vs. Kansas City (W, 30-21)
- Nov. 24: BYE WEEK
- Dec. 1: vs. San Francisco
- Dec. 8: at Los Angeles Rams
- Dec. 15: at Detroit
- Dec. 22: vs. New England
- Dec. 29: vs. New York Jets
- Jan. 5: at New England
- Record: 9-2
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