While the 49ers appear in slightly better shape compared to their injury-marred 2020 season, the team has seen its star-stacked roster run into significant health trouble at an early juncture. Injuries have played a major role in the defending NFC champions’ 1-2 record.
Some of the pieces will return, though Javon Hargrave is not expected to and Christian McCaffrey‘s murky status overshadows the other issues at this point. But Deebo Samuel and George Kittle are practicing again. This comes after Talanoa Hufanga made his season debut against the Rams. The other key San Francisco starter to suffer a late-season injury last year does not appear to be expected to miss the bulk of this campaign, either.
San Francisco is expecting Dre Greenlaw to make a midseason return, according to The Athletic’s Matt Barrows (subscription required). Going down with a historically ill-timed Achilles tear, Greenlaw can be activated from the PUP list beginning in Week 5. That appears ambitious for a player who went down early in Super Bowl LVIII, but the 49ers do not seem likely to wait too much longer for the three-down linebacker to re-emerge.
The team reached multiple contingency plans to cover for Greenlaw’s rehab timetable, agreeing to terms with Eric Kendricks and then De’Vondre Campbell. Kendricks backtracked on his 49ers pledge due to the Cowboys offering him more playing time compared to a 49ers role that would have seen him drift to a part-time performer once Greenlaw recovered. The team then gave Campbell a one-year, $5MM deal to be Fred Warner‘s stopgap sidekick. The Packers had cut Campbell after three seasons.
Campbell committed a costly pass interference penalty late in the Rams’ comeback win Sunday. It is too early for true assessments to be made, but Pro Football Focus ranks Kendricks 21st among off-ball ‘backers while slotting Campbell 54th. Campbell has played 92% of San Francisco’s defensive snaps, while nominal starter/part-time player Demetrius Flannigan-Fowles has logged a 26% snap rate. Greenlaw’s return stands to reduce Campbell’s workload to Flannigan-Fowles’ level or close to it.
Suffering the Achilles tear while trotting onto the field in the first half, Greenlaw had experienced pain in that area in the weeks leading up to the Super Bowl. This bit the 49ers at the worst possible time, as Travis Kelce took advantage of the suddenly depleted LB corps. Greenlaw was immediately deemed out of the picture for the season’s first four weeks, with the PUP list becoming inevitable due to mid-February surgery. No timetable emerged after that designation became official, with this midseason assessment being the closest thing to it. It is worth wondering if the 49ers will factor their Week 9 bye into this equation, though some big games — against the Seahawks and Chiefs — loom in Weeks 6 and 7.
Greenlaw, 27, is signed to a two-year, $16.4MM deal. The sixth-year veteran has a chance at a big payday come 2025, though he will need to return to his pre-tear form. Ex-teammate Azeez Al-Shaair‘s three-year, $34MM Texans deal could represent a viable target. With McCaffrey and Brandon Aiyuk extended this offseason and a Brock Purdy payday looming, the 49ers will have difficult decisions to make on defense. Greenlaw, Hufanga and cornerbacks Charvarius Ward and Deommodore Lenoir are unsigned for 2025. For now, however, this group remains intact to help the 49ers rebound after a slow start. This cadre is poised to include Greenlaw soon.